Article
Co-variation of STI1 and WDR36/UTP21 alters cell proliferation in a glaucoma model.
Molecular vision - 1 Jan 2011
Footz Tim, Dubois Stéphane, Sarfarazi Mansoor, Raymond Vincent, Walter Michael A
Abstract excerpt
PURPOSE: To investigate the role of multigenic variation in primary open-angle glaucoma (POAG) involving the rRNA processing gene WD repeat domain 36 (WDR36). METHODS: We examined the heat shock protein 70/90 (HSP70/90)-organizing co-chaperone stress-induced-phosphoprotein 1 (STI1) as a potential co-modifying gene in glaucoma patients found to harbor WDR36 amino acid variation. The STI1 gene was sequenced and its...
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