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Article

Clearance of genotype 1b hepatitis C virus in chimpanzees in the presence of vaccine-induced E1-neutralizing antibodies.

The Journal of infectious diseases - 15 Sept 2011

Verstrepen Babs E, Depla Erik, Rollier Christine S, Mares Gwenny, Drexhage Joost A R, Priem Sofie, Verschoor Ernst J, Koopman Gerrit, Granier Christelle, Dreux Marlène, Cosset François L, Maertens Geert, Heeney Jonathan L

Abstract excerpt

Accumulating evidence indicates that neutralizing antibodies play an important role in protection from chronic hepatitis C virus (HCV) infection. Efforts to elicit such responses by immunization with intact heterodimeric E1E2 envelope proteins have met with limited success. To determine whether antigenic sites, which are not exposed by the combined E1E2 heterodimer structure, are capable of eliciting neutralizing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21849281
DOI: 10.1093/infdis/jir423
PMCID: PMC3156919

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