Article
Accumulation of HIV-1 drug resistance in patients on a standard thymidine analogue-based first line antiretroviral therapy after virological failure: implications for the activity of next-line regimens from a longitudinal study in Mozambique.
BMC infectious diseases - 5 Sept 2017
De Luca Andrea, Sidumo Zita Jorge, Zanelli Giacomo, Magid Noorjehan Abdul, Luhanga Richard, Brambilla Davide, Liotta Giuseppe, Mancinelli Sandro, Marazzi Maria Cristina, Palombi Leonardo, Ceffa Susanna
Abstract excerpt
BACKGROUND: We describe the accumulation of HIV-1 drug resistance and its effect on the activity of next-line components in patients with virological failure (HIV-1 RNA >1000 copies/mL) after 1 year (t1) of first-line antiretroviral therapy (ART) not switching to second-line drugs for one additional year (t2) in low-middle income countries (LMIC). METHODS AND RESULTS: We selected 48 patients from the DREAM cohort...
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