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Phase II Trial of Nilotinib in Patients With Metastatic Malignant Melanoma Harboring KIT Gene Aberration: A Multicenter Trial of Korean Cancer Study Group (UN10-06).

The oncologist - 1 Nov 2015

Lee Su Jin, Kim Tae Min, Kim Yu Jung, Jang Kee-Taek, Lee Hyo Jin, Lee Soon Nam, Ahn Mi Sun, Hwang In Gyu, Lee Suee, Lee Moon-Hee, Lee Jeeyun

Abstract excerpt

BACKGROUND: KIT has been suggested to be a potential therapeutic target for malignant melanoma. We evaluated the antitumor activity and safety of the KIT inhibitor nilotinib in metastatic melanoma patients harboring KIT gene mutations or amplifications. METHODS: We conducted a phase II multicenter trial of nilotinib in metastatic malignant melanoma with KIT mutations or amplifications. Patients received 400 mg...

Topics

Adult
Aged
Aged, 80 and over
Disease-Free Survival
Female
Gene Amplification
Humans
Male
Melanoma
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Metastasis

Proto-Oncogene Proteins c-kit

Pyrimidines

Source

Open in PubMed Open full text

Identifiers

PMID: 26424760
DOI: 10.1634/theoncologist.2015-0161
PMCID: PMC4718426

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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