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Article

Clinical course of patients with familial early-onset Alzheimer's disease potentially lacking senile plaques bearing the E693Δ mutation in amyloid precursor protein.

Dementia and geriatric cognitive disorders - 1 Jan 2011

Shimada Hiroyuki, Ataka Suzuka, Tomiyama Takami, Takechi Hajime, Mori Hiroshi, Miki Takami

Abstract excerpt

BACKGROUND/AIMS: Oligomeric amyloid β (Aβ) is currently considered to induce Alzheimer's disease (AD). We examined 2 patients with familial AD who possessed the Osaka (E693Δ) mutation in amyloid precursor protein. To the best of our knowledge, these patients are the first AD cases presumably affected with Aβ oligomers in the absence of senile plaques, and they support the Aβ oligomer hypothesis. METHODS: We...

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PMID: 21846988
DOI: 10.1159/000330017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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