Article
Associations of vitamin d binding protein gene polymorphisms with the development of peripheral arthritis and uveitis in ankylosing spondylitis.
The Journal of rheumatology - 1 Oct 2011
Jung Kyong-Hee, Kim Tae-Hwan, Sheen Dong-Hyuk, Lim Mi-Kyoung, Lee Sang-Kwang, Kim Ji-Young, Park Hyo, Chae Soo-Cheon, Shim Seung-Cheol
Abstract excerpt
OBJECTIVE: Genetic factors account for more than 90% of overall susceptibility to ankylosing spondylitis (AS), and recent studies have focused on non-major histocompatibility complex genes. Vitamin D binding protein (DBP) is a highly polymorphic protein that transports vitamin D and its metabolites. In addition to its sterol binding capacity, DBP has many other roles in the inflammatory and immune systems, and...
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