Article
A transcriptional switch in the expression of yeast tricarboxylic acid cycle genes in response to a reduction or loss of respiratory function.
Molecular and cellular biology - 1 Oct 1999
Liu Z, Butow R A
Abstract excerpt
The Hap2,3,4,5p transcription complex is required for expression of many mitochondrial proteins that function in electron transport and the tricarboxylic acid (TCA) cycle. We show that as the cells' respiratory function is reduced or eliminated, the expression of four TCA cycle genes, CIT1, ACO1, IDH1, and IDH2, switches from HAP control to control by three genes, RTG1, RTG2, and RTG3. The expression of four...
Topics
- Aconitate Hydratase
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Binding Sites
- Citrate (si)-Synthase
- Citric Acid Cycle
- DNA-Binding Proteins
- Fungal Proteins
- Gene Deletion
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Genes, Reporter
- Genes, Switch
- Glutamic Acid