A composite likelihood approach to latent multivariate Gaussian modeling of SNP data with application to genetic association testing.

Abstract excerpt

Many statistical tests have been proposed for case-control data to detect disease association with multiple single nucleotide polymorphisms (SNPs) in linkage disequilibrium. The main reason for the existence of so many tests is that each test aims to detect one or two aspects of many possible distributional differences between cases and controls, largely due to the lack of a general and yet simple model for...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biometry
• Share to Computer Simulation
• Share to Genetic Association Studies