Article
Does neoadjuvant therapy alter KRAS and/or MSI results in rectal adenocarcinoma testing?
The American journal of surgical pathology - 1 Sept 2011
Ondrejka Sarah L, Schaeffer David F, Jakubowski Maureen A, Owen David A, Bronner Mary P
Abstract excerpt
To our knowledge, the genotoxic effects of neoadjuvant chemoradiation therapy on molecular diagnostic testing results are unknown. However, if neoadjuvant treatments were to alter molecular test results, clinical decision-making could be misled. This raises questions about the appropriateness of using posttreatment tumor for testing. To address this, rectal adenocarcinomas both before and after neoadjuvant...
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