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Article

Differential effects of RAS mutations on chemoradiotherapy and total neoadjuvant therapy in locally advanced rectal cancer.

International journal of cancer - 15 Nov 2025

Haraguchi Erina, Akiyoshi Takashi, Noguchi Tatsuki, Sakamoto Takashi, Matsui Shimpei, Mukai Toshiki, Yamaguchi Tomohiro, Koyama Masamichi, Taguchi Senzo, Chino Akiko, Kawachi Hiroshi, Shinozaki Eiji, Yamaguchi Kensei

Abstract excerpt

Limited data are available on the impact of RAS mutations in patients with locally advanced rectal cancer treated with total neoadjuvant therapy (TNT). This retrospective study aimed to evaluate the effect of RAS mutations on treatment efficacy in 290 patients with locally advanced rectal cancer without distant metastasis, treated between 2015 and 2021 with neoadjuvant long-course chemoradiotherapy (CRT) with or...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40658108
DOI: 10.1002/ijc.70040

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