Article
Evidence that genes for depression impact on the pathway from trauma to psychotic-like symptoms by occasioning emotional dysregulation.
Psychological medicine - 1 Feb 2012
Kramer I M A, Simons C J P, Myin-Germeys I, Jacobs N, Derom C, Thiery E, van Os J, Wichers M
Abstract excerpt
BACKGROUND: Genes for depression may act by making individuals more sensitive to childhood trauma. Given that childhood adversity is a risk factor for adult psychosis and symptoms of depression and psychosis tend to cluster within individuals and families, the aim was to examine whether the association between childhood adversity and psychotic-like symptoms is moderated by genetic liability for depression. A...
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