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Article

A Bioluminogenic HDAC Activity Assay: Validation and Screening

11 Aug 2011

Abstract excerpt

Histone deacetylase (HDAC) enzymes modify the acetylation state of histones and other important proteins. Aberrant HDAC enzyme function has been implicated in many diseases, and the discovery and development of drugs targeting these enzymes is becoming increasingly important. In this article, the authors report the evaluation of homogeneous, single-addition, bioluminogenic HDAC enzyme activity assays that offer...

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PMID: 21832257
DOI: 10.1177/1087057111416004

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