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Article

A histone deacetylase-dependent screen in yeast.

Bioorganic & medicinal chemistry - 1 Nov 2010

Weerasinghe Sujith V W, Wambua Magdalene, Pflum Mary Kay H

Abstract excerpt

Histone deacetylase (HDAC) proteins are promising targets for cancer treatment, as shown by the recent FDA approval of the HDAC inhibitor suberoylanilide hydroxamic acid (SAHA, Vorinostat) for the treatment of cutaneous T-cell lymphoma. To identify additional potent inhibitors and characterize HDAC mutant proteins, there is interest to develop an inexpensive screening method dependent on native substrates. Here,...

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Identifiers

PMID: 20863708
DOI: 10.1016/j.bmc.2010.08.045
PMCID: PMC3033752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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