Article

MeFluHyA: a novel fluorescent screening tool for high-throughput identification of HDAC6-selective inhibitors

2026-07-27

Abstract excerpt

The cytosolic histone deacetylase 6 (HDAC6) plays a key role not only in cancer but also in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) peripheral neuropathies. Pharmacological inhibition as well as genetic silencing of HDAC6 is able to rescue several defects. Therefore, developing pharmacological compounds targeting this enzyme is of crucial interest. Here, we report the design, synt...

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Literature Corpus work: 0d8bb20a-2b73-5231-92e5-ef994acccf41
DOI: 10.64898/2026.07.24.740064

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