Article
Feasibility of reconstructed ancestral H5N1 influenza viruses for cross-clade protective vaccine development
20 Dec 2010
Abstract excerpt
Since the reemergence of highly pathogenic H5N1 influenza viruses in humans in 2003, these viruses have spread throughout avian species in Asia, Europe, and Africa. Their sustained circulation has resulted in the evolution of phylogenetically diverse lineages. Viruses from these lineages show considerable antigenic variation, which has confounded vaccine planning efforts. We reconstructed ancestral protein...
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