Article
Isochromosome 12p in non-seminoma cell lines: karyologic amplification of c-ki-ras2 without point-mutational activation.
Oncogene - 1 Apr 1990
Dmitrovsky E, Murty V V, Moy D, Miller W H, Nanus D, Albino A P, Samaniego F, Bosl G, Chaganti R S
Abstract excerpt
We examined eight human germ cell cancer lines (GCCLs) for cytogenetic abnormalities and found an isochromosome 12p, i(12p), marker in all seven male nonseminoma GCCLs, but not in the single female teratocarcinoma cell line. Southern blot analysis of these cell lines showed increased copy number for c-ki-ras2, a gene located on 12p, in all the male GCCLs. The comparison of Southern blot analysis for a restriction...
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