Chromosome 12 in human testicular cancer: dosage changes and their parental origin.

doi:10.1016/0165-4608(92)90316-z

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Article

Chromosome 12 in human testicular cancer: dosage changes and their parental origin.

Cancer genetics and cytogenetics - 1 Nov 1992

Peltomäki P, Lothe R A, Børresen A L, Fosså S D, Brøgger A, de la Chapelle A

Abstract excerpt

Cytogenetically, a marker chromosome interpreted as i(12p) is present in most testicular tumors of germ cell origin. In this study, 22 patients with testicular germ-cell tumors were investigated by Southern blot hybridization to characterize changes in chromosome 12. In comparison with normal DNA, tumor DNA of 18 patients showed increased dosages of 12p accompanied by a comparable or smaller increase or no change...

Topics

Alleles
Blotting, Southern
Centromere
Chromosome Aberrations
Chromosomes, Human, Pair 12
DNA, Neoplasm
Dysgerminoma
Genetic Markers
Humans
Male
Mesonephroma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nondisjunction, Genetic

Nucleic Acid Hybridization

Parents

Phenotype

Teratoma

Testicular Neoplasms

Source

Open in PubMed

Identifiers

PMID: 1458445
DOI: 10.1016/0165-4608(92)90316-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1458445-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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