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Article

Chromosomal imbalances associated with carcinoma in situ and associated testicular germ cell tumours of adolescents and adults

1 Jul 2001

Abstract excerpt

Carcinoma in situ (CIS) or intratubular germ cell neoplasia is generally considered the precursor lesion of adult testicular germ cell tumours (TGCT). The chromosomal imbalances associated with CIS and the corresponding seminoma (SE) or nonseminoma (NS) have been determined by comparative genomic hybridization (CGH) analysis of microdissected material from seven cases. Significantly, the CIS showed no gain of 12p...

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Identifiers

PMID: 11461079
DOI: 10.1054/bjoc.2001.1889

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