Article
Holoenzyme DNA polymerase III fixes mutations.
Mutation research - 1 Apr 1990
Bryan S K, Hagensee M, Moses R E
Abstract excerpt
DNA polymerase III is required for mutagenesis after damage to the chromosome. This effect is not modulated by the presence or absence of DNA polymerase II activity in the cell. In cells containing a temperature-sensitive dnaE mutation, the alpha-subunit of DNA polymerase III is inactivated at the restrictive temperature, resulting in lethality. Cells containing the pcbA1 mutation can continue replication if DNA...
Topics
- Aminocoumarins
- Coumarins
- DNA Polymerase I
- DNA Polymerase II
- DNA Polymerase III
- DNA Replication
- DNA, Bacterial
- DNA-Directed DNA Polymerase
- Escherichia coli
- Mutation
- Temperature