Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability.

doi:10.1371/journal.pgen.1002198

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Article

Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability.

PLoS genetics - 1 Jul 2011

Sanna Serena, Li Bingshan, Mulas Antonella, Sidore Carlo, Kang Hyun M, Jackson Anne U, Piras Maria Grazia, Usala Gianluca, Maninchedda Giuseppe, Sassu Alessandro, Serra Fabrizio, Palmas Maria Antonietta, Wood William H, Njølstad Inger, Laakso Markku, Hveem Kristian, Tuomilehto Jaakko, Lakka Timo A, Rauramaa Rainer, Boehnke Michael, Cucca Francesco, Uda Manuela, Schlessinger David, Nagaraja Ramaiah, Abecasis Gonçalo R

Abstract excerpt

Complex trait genome-wide association studies (GWAS) provide an efficient strategy for evaluating large numbers of common variants in large numbers of individuals and for identifying trait-associated variants. Nevertheless, GWAS often leave much of the trait heritability unexplained. We hypothesized that some of this unexplained heritability might be due to common and rare variants that reside in GWAS identified...

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Identifiers

PMID: 21829380
DOI: 10.1371/journal.pgen.1002198
PMCID: PMC3145627

Genes

LDLR
PCSK9
APOE
APOB
APOC1
APOC2
SORT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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