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Article

Rapid induction of colonic adenocarcinoma in mice exposed to benzo[a]pyrene and dextran sulfate sodium.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Nov 2011

Hakura Atsushi, Seki Yuki, Sonoda Jiro, Hosokawa Satoru, Aoki Toyohiko, Suganuma Akiyoshi, Kerns William D, Tsukidate Kazuo

Abstract excerpt

Previously, we reported that the mutation frequency was markedly increased in the colon after the oral treatment of mice with an environmental mutagen/carcinogen, benzo[a]pyrene (BP); however this was not followed by tumor development. The reasons for this are as yet unresolved. The purpose of the present study is to explore the mechanisms why a high frequency of mutations induced by BP in the colon is not...

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Identifiers

PMID: 21827817
DOI: 10.1016/j.fct.2011.07.057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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