Pyridoxal 5'-phosphate-dependent histidine decarboxylase. Mechanism of inactivation by alpha-fluoromethylhistidine.

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Article

Pyridoxal 5'-phosphate-dependent histidine decarboxylase. Mechanism of inactivation by alpha-fluoromethylhistidine.

The Journal of biological chemistry - 25 Apr 1990

Bhattacharjee M K, Snell E E

Abstract excerpt

Mechanism-based inactivation of pyridoxal phosphate-dependent histidine decarboxylase by (S)-alpha-(fluoromethyl)histidine was studied. The molar ratio of inactivator to enzyme subunit required for complete inactivation increased from 1.63 at 10 degrees C to 3.00 at 37 degrees C. Two inactivation...

Topics

Carboxy-Lyases
Escherichia coli
Histidine
Histidine Decarboxylase
Kinetics
Magnetic Resonance Spectroscopy
Methylhistidines
Molecular Structure
Mutation
Plasmids
Pyridoxal Phosphate
Recombinant Proteins
Spectrophotometry

Source

Open in PubMed

Identifiers

PMID: 2182624

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2182624-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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