Article
Mutations of optineurin in amyotrophic lateral sclerosis.
Nature - 13 May 2010
Maruyama Hirofumi, Morino Hiroyuki, Ito Hidefumi, Izumi Yuishin, Kato Hidemasa, Watanabe Yasuhito, Kinoshita Yoshimi, Kamada Masaki, Nodera Hiroyuki, Suzuki Hidenori, Komure Osamu, Matsuura Shinya, Kobatake Keitaro, Morimoto Nobutoshi, Abe Koji, Suzuki Naoki, Aoki Masashi, Kawata Akihiro, Hirai Takeshi, Kato Takeo, Ogasawara Kazumasa, Hirano Asao, Takumi Toru, Kusaka Hirofumi, Hagiwara Koichi, Kaji Ryuji, Kawakami Hideshi
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) has its onset in middle age and is a progressive disorder characterized by degeneration of motor neurons of the primary motor cortex, brainstem and spinal cord. Most cases of ALS are sporadic, but about 10% are familial. Genes known to cause classic familial AL...
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