Article
Protease phenotype of constitutive connective tissue and of induced mucosal mast cells in mice is regulated by the tissue.
Proceedings of the National Academy of Sciences of the United States of America - 23 Aug 2011
Xing Wei, Austen K Frank, Gurish Michael F, Jones Tatiana G
Abstract excerpt
Mouse mast cells (MCs) express a large number of serine proteases including tryptases, mouse mast cell protease (mMCP)-6 and -7; chymases, mMCP-1, -2, and -4; and an elastase, mMCP-5; along with carboxypeptidase-A3 (CPA3). In helminth-infected mouse intestine, distinct protease phenotypes are observed for connective tissue MCs (CTMCs) (mMCP-4(+)-7(+), and CPA3(+)) and mucosal MCs (MMCs) (mMCP-1(+) and 2(+)). To...
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