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Article

Oxidative stress and androgen receptor signaling in the development and progression of castration-resistant prostate cancer.

Free radical biology & medicine - 1 Oct 2011

Shiota Masaki, Yokomizo Akira, Naito Seiji

Abstract excerpt

Aberrant androgen receptor (AR) signaling plays a critical role in androgen-dependent prostate cancer (PCa), as well as in castration-resistant PCa (CRPC). Oxidative stress seems to contribute to the tumorigenesis and progression of PCa, as well as the development of CRPC, via activation of AR signaling. This notion is supported by the fact that there is an aberrant or improper regulation of the redox status in...

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Identifiers

PMID: 21820046
DOI: 10.1016/j.freeradbiomed.2011.07.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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