Article
Heterogeneity of the tumorigenic phenotype expressed by Madin-Darby canine kidney cells.
Comparative medicine - 1 Jun 2011
Omeir Romelda L, Teferedegne Belete, Foseh Gideon S, Beren Joel J, Snoy Philip J, Brinster Lauren R, Cook James L, Peden Keith, Lewis Andrew M
Abstract excerpt
The mechanisms by which cells spontaneously immortalized in tissue culture develop the capacity to form tumors in vivo likely embody fundamental processes in neoplastic development. The evolution of Madin-Darby canine kidney (MDCK) cells from presumptively normal kidney cells to immortalized cells that become tumorigenic represents an example of neoplastic development in vitro. Studies of the mechanisms by which...
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