Article
Concise review: transmissible animal tumors as models of the cancer stem-cell process.
Stem cells (Dayton, Ohio) - 1 Dec 2011
O'Neill Iain D
Abstract excerpt
Tasmanian devil facial tumor disease (DFTD) and canine transmissible venereal tumor (CTVT) are highly unusual cancers capable of being transmitted between animals as an allograft. The concept that these tumors represent a cancer stem-cell process has never been formally evaluated. For each, evidence of self-renewal is found in the natural history of these tumors in the wild, tumor initiation in recipient animals,...
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