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Preclinical SC and IV repeat-dose toxicology of a cowpea mosaic virus – A cancer immunotherapy candidate

8 Apr 2025

Abstract excerpt

Cancer immunotherapies focus on boosting the immune system to recognize and eliminate tumor cells. Amongst the various biologics under development for cancer immunotherapy, our team has focused on the study of plant viruses in this context. We have shown that intratumoral administration of cowpea mosaic virus (CPMV) relieves the immunosuppressive tumor microenvironment and elicits a potent, systemic and durable...

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PMID: 40276251
DOI: 10.1016/j.toxrep.2025.102022

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