Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Smoking is associated with, but does not cause, depressed mood in pregnancy--a mendelian randomization study.

PloS one - 1 Jan 2011

Lewis Sarah J, Araya Ricardo, Smith George Davey, Freathy Rachel, Gunnell David, Palmer Tom, Munafò Marcus

Abstract excerpt

Smokers have a higher prevalence of major depressive episodes and depressive symptoms than the general population, but whether this association is causal, or is due to confounding or reverse causation is uncertain because of the problems inherent in some epidemiological studies. Mendelian randomization, in which a genetic variant is used as a surrogate for measuring exposure, is an approach which may be used to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Affect
Share to Depression
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to Pregnancy

Share to Risk Factors

Share to Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 21818261
DOI: 10.1371/journal.pone.0021689
PMCID: PMC3139580

Genes

CHRNA3
CHRNA5
CHRNB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Smoking is associated with, but does not cause, depressed mood in pregnancy--a mendelian randomization study.PMID 21818261Read ↗

Using Mendelian randomisation to infer causality in depression and anxiety research.Semantic proximity Read ↗

The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study.Semantic proximity Read ↗

Applying Mendelian randomization to appraise causality in relationships between smoking, depression and inflammation.Semantic proximity Read ↗

A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.Semantic proximity Read ↗

Proxy gene-by-environment Mendelian randomization study of the association between cigarette smoking during pregnancy and offspring mental health.Semantic proximity Read ↗

Genetics of smoking and depressionSemantic proximity Read ↗

Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortiumSemantic proximity Read ↗

Association Between rs1051730 and Smoking During Pregnancy in Dutch Women.Semantic proximity Read ↗

Dopamine and opioid gene variants are associated with increased smoking reward and reinforcement owing to negative mood.Semantic proximity Read ↗

Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation studySemantic proximity Read ↗

[Maternal bonding style, cholinergic receptor gene polymorphisms in association with smoking-related depressive symptoms].Semantic proximity Read ↗

The effects of the DRD2 polymorphism on smoking cessation and negative affect: evidence for a pharmacogenetic effect on mood.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.