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Article

Adrenomedullin 2/Intermedin Regulates HLA-G in Human Trophoblasts1

5 Aug 2011

Abstract excerpt

Adrenomedullin 2 (ADM2), also referred to as intermedin (IMD), is expressed in trophoblast cells in human placenta and enhances the invasion and migration of first-trimester HTR-8SV/neo cells. Further infusion of ADM2 antagonist in pregnant rat causes fetoplacental growth restriction, suggesting a role for ADM2 in maintaining a successful pregnancy. This study was undertaken to assess whether ADM2 protein is...

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PMID: 21816853
DOI: 10.1095/biolreprod.110.086835

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