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Article

Ex vivo expanded hematopoietic stem cells overcome the MHC barrier in allogeneic transplantation.

Cell stem cell - 5 Aug 2011

Zheng Junke, Umikawa Masato, Zhang Shichuan, Huynh HoangDinh, Silvany Robert, Chen Benjamin P C, Chen Lieping, Zhang Cheng Cheng

Abstract excerpt

The lack of understanding of the interplay between hematopoietic stem cells (HSCs) and the immune system has severely hampered the stem cell research and practice of transplantation. Major problems for allogeneic transplantation include low levels of donor engraftment and high risks of graft-versus-host disease (GVHD). Transplantation of purified allogeneic HSCs diminishes the risk of GVHD but results in...

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Identifiers

PMID: 21816363
DOI: 10.1016/j.stem.2011.06.003
PMCID: PMC3151486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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