Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A new lead from genetic studies in depressed siblings: assessing studies of chromosome 3.

The American journal of psychiatry - 1 Aug 2011

Hamilton Steven P

Abstract excerpt

Studies by Breen et al. and Pergadia et al. find evidence for genetic linkage between major depressive disorder and the same region on chromosome 3. The linked region contains the gene GRM7, which encodes a protein for the metabotropic glutamate receptor 7 (mGluR7). Both studies used affected sibling pairs, and neither was able to replicate its finding using association studies in individuals from larger...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 3
Share to Genetic Linkage
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Major Depressive Disorder

Share to Phenotype

Share to Receptors, Metabotropic Glutamate

Share to Siblings

Source

Identifiers

PMID: 21813496
DOI: 10.1176/appi.ajp.2011.11060835

Genes

GRM7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A new lead from genetic studies in depressed siblings: assessing studies of chromosome 3.PMID 21813496Read ↗

A genome-wide significant linkage for severe depression on chromosome 3: the depression network study.Semantic proximity Read ↗

Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder.Semantic proximity Read ↗

Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.Semantic proximity Read ↗

Resequencing three candidate genes for major depressive disorder in a Dutch cohort.Semantic proximity Read ↗

Association study of GRM7 polymorphisms with major depressive disorder in the Chinese Han population.Semantic proximity Read ↗

Significant association of GRM7 and GRM8 genes with schizophrenia and major depressive disorder in the Han Chinese population.Semantic proximity Read ↗

A family-based association study of DNA sequence variants in GRM7 with schizophrenia in an Indonesian population.Semantic proximity Read ↗

The Depression Network (DeNT) Study: methodology and sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetic study.Semantic proximity Read ↗

No evidence for association between polymorphisms in GRM3 and schizophrenia.Semantic proximity Read ↗

Whole genome linkage scan of recurrent depressive disorder from the depression network study.Semantic proximity Read ↗

A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families.Semantic proximity Read ↗

Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.