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RAD50 and NBS1 are not likely to be susceptibility genes in Chinese non-BRCA1/2 hereditary breast cancer.

Breast cancer research and treatment - 1 May 2012

He Min, Di Gen-Hong, Cao A-Yong, Hu Zhen, Jin Wei, Shen Zhen-Zhou, Shao Zhi-Ming

Abstract excerpt

Deleterious mutations in several genes that are involved in repair of damage to DNA have been associated with an increased risk of breast cancer. Recent studies have shown sequence variants in two such genes, RAD50 and NBS1, which can be predisposed to breast cancer. The aim of this study is to elucidate the contribution of RAD50 and NBS1 germline mutations to the etiology of non-BRCA1/2 hereditary breast cancer...

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Source

Identifiers

PMID: 21811815
DOI: 10.1007/s10549-011-1700-2

Genes

RAD50
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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RAD50 and NBS1 are not likely to be susceptibility genes in Chinese non-BRCA1/2 hereditary breast cancer.PMID 21811815Read ↗

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rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk.Semantic proximity Read ↗

RAD51C germline mutations in Chinese women with familial breast cancerSemantic proximity Read ↗

Associations between NBS1 Polymorphisms and Colorectal Cancer in Chinese Population.Semantic proximity Read ↗

RAD50 germline mutations are associated with poor survival in BRCA1/2-negative breast cancer patients.Semantic proximity Read ↗

Rad50 c.687delT does not contribute significantly to familial breast cancer in a French population.Semantic proximity Read ↗

Current evidence on the relationship between two polymorphisms in the NBS1 gene and breast cancer risk: a meta-analysis.Semantic proximity Read ↗

Expanding the mutational spectrum of RAD50: a case report of Nijmegen breakage syndrome-like disorder in a Chinese child.Semantic proximity Read ↗

Functional polymorphisms in the NBS1 gene and acute lymphoblastic leukemia susceptibility in a Chinese population.Semantic proximity Read ↗

Association between the NBS1 Glu185Gln polymorphism and breast cancer risk: a meta-analysis.Semantic proximity Read ↗

Polymorphisms and haplotypes of the NBS1 gene are associated with risk of sporadic breast cancer in non-Hispanic white women <or=55 years.Semantic proximity Read ↗

RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability.Semantic proximity Read ↗

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