Article
Reduced signaling through the hedgehog pathway in the uterine stroma causes deferred implantation and embryonic loss.
Reproduction (Cambridge, England) - 1 May 2011
Harman Rebecca M, Cowan Robert G, Ren Yi, Quirk Susan M
Abstract excerpt
The role of the hedgehog (HH) signaling pathway in implantation was studied in mice in which the HH signal transducer, smoothened (SMO), was conditionally deleted in the stromal compartment of the uterus, using CRE recombinase expressed through the Amhr2(cre) allele. In Amhr2(cre/+)Smo(null/flox)-mutant mice, Smo mRNA in uterine stroma was reduced 49% compared to that in Amhr2(+/+)Smo(null/flox) control mice,...
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