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Article

Protection of neuronal calcium sensor 1 protein in cells treated with paclitaxel.

The Journal of biological chemistry - 7 Oct 2011

Benbow Jennifer H, DeGray Brenda, Ehrlich Barbara E

Abstract excerpt

Paclitaxel (Taxol) is one of the most effective treatment options for patients suffering from a variety of cancers. A major side effect seen in a high percentage of patients treated with paclitaxel is irreversible peripheral neuropathy. We previously reported that prolonged treatment with paclitaxel activates a calcium-dependent enzyme, calpain, which degrades neuronal calcium sensor 1 (NCS-1) and subsequent loss...

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Identifiers

PMID: 21808066
DOI: 10.1074/jbc.M111.265751
PMCID: PMC3186436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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