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The Tumor Suppressor TPD52‐Governed Endoplasmic Reticulum Stress is Modulated by APCCdc20

14 Oct 2024

Abstract excerpt

Abstract Aberrant regulation of unfolded protein response (UPR)/endoplasmic reticulum (ER) stress pathway is associated with cancer development, metastasis, and relapse, and the UPR signal transducer ATF6 has been proposed as a diagnostic and prognostic marker for many cancers. However, a causal molecular link between ATF6 activation and carcinogenesis is not established. Here, it is found that tumor protein D52...

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PMID: 39401430
DOI: 10.1002/advs.202405441

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