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Article

Direct interaction between a myosin V motor and the Rab GTPases Ypt31/32 is required for polarized secretion.

Molecular biology of the cell - 1 Oct 2008

Lipatova Zhanna, Tokarev Andrei A, Jin Yui, Mulholland Jon, Weisman Lois S, Segev Nava

Abstract excerpt

Rab GTPases recruit myosin motors to endocytic compartments, which in turn are required for their motility. However, no Ypt/Rab GTPase has been shown to regulate the motility of exocytic compartments. In yeast, the Ypt31/32 functional pair is required for the formation of trans-Golgi vesicles. The myosin V motor Myo2 attaches to these vesicles through its globular-tail domain (GTD) and mediates their polarized...

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Source

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Identifiers

PMID: 18653471
DOI: 10.1091/mbc.e08-02-0220
PMCID: PMC2555963

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Direct interaction between a myosin V motor and the Rab GTPases Ypt31/32 is required for polarized secretion.PMID 18653471Read ↗

Complex formation with Ypt11p, a rab-type small GTPase, is essential to facilitate the function of Myo2p, a class V myosin, in mitochondrial distribution in Saccharomyces cerevisiae.Semantic proximity Read ↗

Kinesin-related Smy1 enhances the Rab-dependent association of myosin-V with secretory cargo.Semantic proximity Read ↗

PI4P and Rab inputs collaborate in myosin-V-dependent transport of secretory compartments in yeast.Semantic proximity Read ↗

Ypt11 functions in bud-directed transport of the Golgi by linking Myo2 to the coatomer subunit Ret2.Semantic proximity Read ↗

The myosin-related motor protein Myo2 is an essential mediator of bud-directed mitochondrial movement in yeast.Semantic proximity Read ↗

The yeast kinesin-related protein Smy1p exerts its effects on the class V myosin Myo2p via a physical interaction.Semantic proximity Read ↗

Two distinct regions in a yeast myosin-V tail domain are required for the movement of different cargoes.Semantic proximity Read ↗

A Ypt32p Exchange Factor Is a Putative Effector of Ypt1pSemantic proximity Read ↗

A type V myosin (Myo2p) and a Rab-like G-protein (Ypt11p) are required for retention of newly inherited mitochondria in yeast cells during cell division.Semantic proximity Read ↗

The COOH-terminal domain of Myo2p, a yeast myosin V, has a direct role in secretory vesicle targeting.Semantic proximity Read ↗

The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarity.Semantic proximity Read ↗

Endocytic recycling in yeast is regulated by putative phospholipid translocases and the Ypt31p/32p-Rcy1p pathway.Semantic proximity Read ↗

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