Article
Effect of N-methionine-free, bacterially synthesized recombinant human granulocyte-macrophage colony-stimulating factor in a primate model.
European journal of haematology - 1 Feb 1990
Akashi K, Taniguchi S, Teshima T, Shibuya T, Okamura T, Harada M, Niho Y
Abstract excerpt
We demonstrate the in vivo effects of bacterially synthesized, N-methionine-free recombinant human granulocyte-macrophage colony stimulating factor (rh GM-CSF) using a crab-eating monkey model. Monkeys were treated with cyclophosphamide (60 mg/kg) and administered with rh GM-CSF (30 micrograms/kg...
Topics
- Animals
- Colony-Forming Units Assay
- Colony-Stimulating Factors
- Cyclophosphamide
- Escherichia coli
- Granulocyte-Macrophage Colony-Stimulating Factor
- Growth Substances
- Hematopoietic Stem Cells
- Leukocyte Count
- Macaca fascicularis
- Male
- Methionine
- Mutation
- Platelet Count
- Recombinant Proteins
- Reference Values