Article
In vitro and in vivo hematopoietic effect of mutant human granulocyte colony-stimulating factor.
Blood - 1 May 1990
Okabe M, Asano M, Kuga T, Komatsu Y, Yamasaki M, Yokoo Y, Itoh S, Morimoto M, Oka T
Abstract excerpt
About 100 derivatives of human recombinant granulocyte colony-stimulating factor (rhG-CSF) were created by various gene-mutagenic techniques, and KW-2228, in which amino acids were replaced at five positions of N-terminal region of intact rhG-CSF, was picked up and evaluated for its biologic and...
Topics
- Animals
- Bone Marrow Cells
- Cell Division
- Colony-Forming Units Assay
- Colony-Stimulating Factors
- Granulocyte Colony-Stimulating Factor
- Hematopoietic Stem Cells
- Humans
- Kinetics
- Male
- Mice
- Mice, Inbred C3H
- Mutation
- Recombinant Proteins