Article
Molecular mechanism underlying 1,25-dihydroxyvitamin D regulation of nephrin gene expression.
The Journal of biological chemistry - 16 Sept 2011
Deb Dilip K, Wang Youli, Zhang Zhongyi, Nie Hongguang, Huang Xueshi, Yuan Zhengwei, Chen Yunzi, Zhao Qun, Li Yan Chun
Abstract excerpt
Nephrin plays a key role in maintaining the structure of the slit diaphragm in the glomerular filtration barrier. Our previous studies have demonstrated potent renoprotective activity for 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)). Here we showed that in podocytes 1,25(OH)(2)D(3) markedly stimulated nephrin mRNA and protein expression. ChIP scan of the 6-kb 5' upstream region of the mouse nephrin gene identified...
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