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Article

MTHFR 677C>T polymorphism increases the male infertility risk: a meta-analysis involving 26 studies.

PloS one - 1 Jan 2015

Gong Mancheng, Dong Wenjing, He Tingyu, Shi Zhirong, Huang Guiying, Ren Rui, Huang Sichong, Qiu Shaopeng, Yuan Runqiang

Abstract excerpt

BACKGROUND AND OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) polymorphism may be a risk factor for male infertility. However, the epidemiologic studies showed inconsistent results regarding MTHFR polymorphism and the risk of male infertility. Therefore, we performed a meta-analysis of published case-control studies to re-examine the controversy. METHODS: Electronic searches of PubMed, EMBASE, Google...

Topics

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Ethnicity
Genetic Predisposition to Disease
Infertility, Male
Methylenetetrahydrofolate Reductase (NADPH2)
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 25793386
DOI: 10.1371/journal.pone.0121147
PMCID: PMC4368707

Genes

MTHFR
OAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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