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Article

Genome-wide association study of epirubicin-induced leukopenia in Japanese patients.

Pharmacogenetics and genomics - 1 Sept 2011

Srinivasan Yuvaraj, Sasa Mitsunori, Honda Junko, Takahashi Atsushi, Uno Satoko, Kamatani Naoyuki, Kubo Michiaki, Nakamura Yusuke, Zembutsu Hitoshi

Abstract excerpt

OBJECTIVES: Despite long-term clinical experience with epirubicin, unpredictable severe adverse reactions remain an important determinant to limit the drug use. To identify a genetic factor(s) affecting the risk of epirubicin-induced leukopenia/neutropenia, we performed a genome-wide association study. METHODS: We studied 270 patients consisting of 67 patients with grade 3 or 4 leukopenia/neutropenia, and 203...

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PMID: 21799462
DOI: 10.1097/FPC.0b013e328348e48f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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