Article
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
Cancer science - 1 Aug 2013
Low Siew-Kee, Chung Suyoun, Takahashi Atsushi, Zembutsu Hitoshi, Mushiroda Taisei, Kubo Michiaki, Nakamura Yusuke
Abstract excerpt
Chemotherapeutic agents are notoriously known to have a narrow therapeutic range that often results in life-threatening toxicity. Hence, it is clinically important to identify the patients who are at high risk for severe toxicity to certain chemotherapy through a pharmacogenomics approach. In this study, we carried out multiple genome-wide association studies (GWAS) of 13 122 cancer patients who received...
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