Article
Sequence-dependent structural variations of DNA revealed by DNase I.
Nucleic acids research - 25 Feb 1990
Brukner I, Jurukovski V, Savic A
Abstract excerpt
Two global helix parameters important for DNA-DNase I interaction are the geometry of the minor groove and the DNA stiffness that resists bending toward major groove. Thus, local averaging of P-O3' bonds cutting frequencies (InP) reflects global helix parameters revealed by DNase I. Using the approximation that locally averaged InP values depend only on the type of the dinucleotide steps involved in the region of...
Topics
- Base Sequence
- DNA
- Deoxyribonuclease I
- Escherichia coli
- Genetic Variation
- Molecular Sequence Data
- Nucleic Acid Conformation
- Plasmids
- Promoter Regions, Genetic