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Article

Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer’s disease

1 Dec 2019

Abstract excerpt

Alzheimer's disease (AD) is an aging-related neurological disorder characterized by synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction pathway that regulates numerous cellular processes including cell survival. In brain, Wnt/β-catenin signaling is not only crucial for neuronal survival and neurogenesis, but it plays important roles in regulating synaptic plasticity and...

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PMID: 31801553
DOI: 10.1186/s13041-019-0525-5

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