Article
Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history.
PloS one - 1 Jan 2013
Aida Junko, Yokoyama Akira, Shimomura Naotaka, Nakamura Ken-ichi, Ishikawa Naoshi, Terai Masanori, Poon Steven, Matsuura Masaaki, Fujiwara Mutsunori, Sawabe Motoji, Arai Tomio, Takubo Kaiyo
Abstract excerpt
Chromoendoscopy with Lugol iodine staining provides important information on the development of squamous cell carcinoma (SCC). In particular, distinct iodine-unstained lesions (DIULs) larger than 10 mm show a high prevalence in high-grade intraepithelial neoplasia. It has also been reported that inactive ALDH2*1/*2 and less-active ADH1B*1/*1, and smoking, are risk factors for esophageal SCC. We previously...
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