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Human meiotic progression and recombination are affected by Bisphenol A exposure during in vitro human oocyte development

26 Jul 2011

Abstract excerpt

BACKGROUND: Bisphenol A (BPA) is a 'weak' endocrine disruptor. The effect of BPA on human reproduction is controversial but has been related to meiotic anomalies, recurrent miscarriages and abnormal karyotypes. METHODS: To evaluate the effects of BPA on survival, pairing-synapsis and meiotic recombination of human fetal oocytes, 21 510 oocytes from 12 cultured fetal ovaries were analyzed. Ovaries were cultured...

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PMID: 21795248
DOI: 10.1093/humrep/der249

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