Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport.

doi:10.1016/j.neurobiolaging.2011.06.006

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Article

Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport.

Neurobiology of aging - 1 Apr 2012

Kanaan Nicholas M, Morfini Gerardo, Pigino Gustavo, LaPointe Nichole E, Andreadis Athena, Song Yuyu, Leitman Ellen, Binder Lester I, Brady Scott T

Abstract excerpt

Alzheimer's disease (AD) and other tauopathies are characterized by fibrillar inclusions composed of the microtubule-associated protein, tau. Recently, we demonstrated that the N-terminus of tau (amino acids [aa] 2-18) in filamentous aggregates or N-terminal tau isoforms activate a signaling cascade involving protein phosphatase 1 and glycogen synthase kinase 3 that results in inhibition of anterograde fast...

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Identifiers

PMID: 21794954
DOI: 10.1016/j.neurobiolaging.2011.06.006
PMCID: PMC3272324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.