Article
New insights into the genetics and epigenetics of systemic sclerosis.
Nature reviews. Rheumatology - 1 Nov 2018
Angiolilli Chiara, Marut Wioleta, van der Kroef Maarten, Chouri Eleni, Reedquist Kris A, Radstake Timothy R D J
Abstract excerpt
Systemic sclerosis (SSc) is a severe autoimmune disease that is characterized by vascular abnormalities, immunological alterations and fibrosis of the skin and internal organs. The results of genetic studies in patients with SSc have revealed statistically significant genetic associations with disease manifestations and progression. Nevertheless, genetic susceptibility to SSc is moderate, and the functional...
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