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Article

Generation of Germline-Competent Rat Induced Pluripotent Stem Cells

15 Jul 2011

Abstract excerpt

BACKGROUND: Recent progress in rat pluripotent stem cell technology has been remarkable. Particularly salient is the demonstration that embryonic stem cells (ESCs) in the rat (rESCs) can contribute to germline transmission, permitting generation of gene-modified rats as is now done using mouse ESCs (mESCs) or mouse induced pluripotent stem cells (iPSCs; miPSCs). However, determinations of whether rat iPSCs...

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PMID: 21789202
DOI: 10.1371/journal.pone.0022008

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